Officers seized two loaded handguns, 50 fentanyl pills, 15 grams of crystal methamphetamine and $3,500 in cash.
The investigation continued later that evening, when police served a high-risk warrant on a home on Rita Crescent just after midnight on Sept. 30.
Police say they found 641 fentanyl pills, 170 grams of crystal methamphetamine, three handguns, including two that were loaded, ammunition, prohibited magazines and about $57,400 in cash.
Several people were taken into custody from that location.
A total of six men aged between 18 and 28 now face a list of charges including possession for the purpose of trafficking, possession of the proceeds of crime and numerous firearm-related charges. Seven people were released without being charged.
The six men appeared in Saskatoon Provincial Court on Friday afternoon.
The arrests were the result of an investigation by members of the Saskatoon Integrated Drug Enforcement Team, with help from the Tactical Support Unit.