The deaths bring this year’s Victorian road toll to 90, compared to 76 for the same period in 2015.
Police say driving while distracted or impaired were factors in the latest fatalities.
Assistant Commissioner Doug Fryer says police have not seen this rate of road fatalities since 2008.
“We are so concerned with the way we are tracking,” he told reporters on Saturday.
Victoria could top 300 road fatalities by the end of the year if the current rate continues, Mr Fryer said.
“We’ve had six families torn apart. Sadly, all of those were avoidable.”
Police say they are doing everything they can to try to make roads safer, but it’s also up to the community.
“There is some fallibility, but we can’t police our way out of road trauma, we can’t police our way out of fatalities on the road,” Mr Fryer said.
“There is an enormous part here for community responsibility to look after each other.”
Three people lost their lives in a collision between a truck and a car in Burrumbeet, near Ballarat, about midnight on Saturday.
Two men, aged 81 and 82, died at the scene, while a 76-year-old woman died in hospital after being airlifted there.
One woman remains in a critical condition and is expected to pull through.
Police say the car pulled out in front of a B-double truck travelling at 100km/h while crossing a highway.
The truck driver, who was not injured, has told police he was unable to stop when he saw the car.
“The truck driver is absolutely devastated,” Mr Fryer said.
On Saturday, a man died when his car crashed into a tree in Myrtleford, northeast of Victoria, just before 10am.
About 5.30am another driver hit a tree on private property in Hunts Rd in Tuerong, and he died at the scene.
A man in his 20s died on Friday night following a car crash in Hopetoun in Victoria’s northwest.
Police say he lost control of his car and it crashed into a tree by the Henty Highway.