In the research, scientists showed that a cannabinoid receptor, called “CB2,” helps regulate the creation of sperm. Not only does this provide more evidence that marijuana can disrupt fertility in males, but it also suggests a therapeutic strategy for treating male infertility.
Researcher Paola Grimaldi from the University of Rome Tor Vergata said that the possibility to improve male fertility is one of the main focuses of this study, since infertility is a worldwide problem that affects up to 15 percent of couples, in which male factors account for almost 20-70 percent.
To make their discovery, Grimaldi and colleagues treated three groups of mice with different agents for 14 to 21 days. The first group was treated with a specific activator of the CB2 receptor. The second group was treated with a specific inhibitor of the CB2 receptor. The third group received only a saline solution and served as the control group.