Paramedics were called, but he was pronounced dead at the scene.
It’s believed he was riding with a number of other motorcyclists at Strath Creek, but no one else was injured in the crash.
Police are trying to determine what led to the incident.
Footage from the crash site showed how the caravan had been damaged on its front right side.
More than 40 motorcyclists have died on the state’s roads so far this year, making up about one in five road deaths.
Police, along with road safety experts, held high-level talks in recent weeks to discuss ways of lowering the road toll among riders.
Let these lives not be lost in vain,” Assistant Commissioner for Road Policing, Doug Fryer, said last month.
Anyone who witnessed the crash should call Crime Stoppers on 1800 333 000 or visit www.crimestoppersvic.com.au.