RCMP say the crash, west of Lickman Road, occurred around 7:45 a.m. PT and resulted in the closure of the highway.
A collision reconstructionist was dispatched to the scene. The B.C. Coroners Service is also investigating.
The highway was closed for hours while the accident was investigated but has since reopened.
Police say they are still searchng for witnesses and ask anyone with information about the crash to contact the Fraser Valley RCMP.