The bus which was ferrying over 55 persons was on its way to Rekong Peo, when the mishap took place near Jogindernagar in Mandi district.
Police officials reached on the spot to rescue the victims. The injured were then rushed to the nearby PGI Chandigarh, Government Medical College, Tanda (Kangra) and other hospitals.
Eight bodies have been retrieved from the wreckage of the bus by Sunday morning.
The condition of some of the injured persons was critical, according to the police.
The rescue operations are in progress with the deceased victims yet to identified. Further details are awaited.
With inputs from agencies