Madhuurima was born and brought up in Mumbai, Maharashtra. Madhuurima’s father is a mechanical engineer who served in the Indian Navy, before he began working as the general manager of the largest private shipyard of India. Her mother had been working as researcher in the field of virology and as a content writer for multinational companies and later turned a novelist. Madhurima has one brother who is four years younger to her. She has completed her Bachelor of Laws with an LLB degree.
Madhuurima made her feature film debut in Toss: A Flip of Destiny (2009). The same year she appeared in her first Telugu film. She went on to act in three Telugu projects within the next one year, including the female lead role in Vamsy’s Saradaga Kasepu and a cameo role in Orange, directed by Bhaskar. However, none of the Telugu films helped her career.In 2012, her second Bollywood film Kamaal Dhamaal Malamaal directed by Priyadarshan released. Next year she appeared in two Telugu films Mahankali and Shadow. She had also signed for the Tamil remake of the Hindi film Ab Tak Chhappan, Kadamai Kanniyam Kattupadu, which was later renamed as Eepeeko,but the film was later released under the title En Vazhi Thani Vazhi (2015) and her role was removed.