Victoria Police spokeswoman Amelia Penhall said: “A number of people were injured in the incident”
Some of the men were believed to be wearing Hawthorn scarves and jumpers.
Ambulance Victoria spokesman John Mullen said one man, aged in his 30s, was taken to the Royal Melbourne Hospital with a head injury.
“He was in a serious but stable condition,” Mr Mullen said.
“Nobody else was assessed at the scene.”
Detectives continue to investigate the brawl. Witnesses or anyone with information is urged to contact Crime Stoppers on 1800 333 000.