Investigators said the northbound car lost control on a curve in the road and rolled.
There were five occupants from Big Island Lake Cree Territory in the vehicle.
The 59-year-old driver was pronounced dead at the scene. His name has not been released by police.
The four surviving passengers were taken by ambulance to hospital in Cold Lake with undetermined injuries.
An RCMP collision reconstructionist attended the crash scene. The cause of the rollover is under investigation.