A 2007 Chevrolet Cobalt had been travelling westbound when it lost control, entered the centre median and rolled into the eastbound lanes, police said in a news release.
Police found the driver — the vehicle’s lone occupant — on the roadway.
She was transported to hospital where she died.
Police believe the driver was not wearing a seatbelt. Alcohol may have been a factor in the crash.
The crash remains under investigation.
The death is the 17th traffic fatality in Edmonton this year.