A National Weather Service damage assessment team was on its way to Mayfield, the agency said. First Baptist Church of Mayfield opened its fellowship hall and said displaced families were already arriving for emergency shelter.
A tornado also touched down about 5:40 p.m. south of Greenville in Muhlenberg County. The National Weather Service warned that flying debris could be deadly and that the tornado would likely destroy mobile homes.
And a third tornado was confirmed about 6:10 p.m. west of Morganfield in Union County, the weather service reported. No reports of damage or injuries were immediately available.
Ari Sarsalari, a meteorologist for The Weather Channel, said potentially dangerous tornadoes were possible through the evening for a large area covering most of Kentucky, southern Indiana, Illinois and Ohio, northern Tennessee and northeast Missouri.
The storms are part of the same system that spawned at least eight confirmed tornadoes in Oklahoma, where two people were killed.