A woman is dead after a fatal crash on Hwy. 401 near Keele St. early Thursday morning. The two-vehicle collision closed all express lanes for about four hours on Hwy. 401 westbound from Avenue Rd. to Hwy. 400.

The incident occurred around 1:15 a.m.

The victim was pronounced dead on scene, and the other driver was taken to hospital with non-life threatening injuries, Toronto paramedics said.

Thursday morning was problematic on other 400 series highways as well.

A serious crash between an SUV and a truck sent seven people to the hospital and closed two lanes on the eastbound Highway 401 near Highway 6 North in Cambridge around 3 a.m.

Four people ended up trapped in the SUV and one was ejected, Sgt. Kerry Schmidt of the Ontario Provincial Police said in a Periscope video.

The video showed massive damage to both vehicles after the SUV rear-ended the truck. “You can see the highway guardrail is completely obliterated and torn to pieces,” Schmidt says. It’s “amazing that it’s not a fatality at this point.”

There is an ongoing investigation about the cause of the crash. He is asking any witnesses to call Cambridge OPP.

Traffic around Cambridge is drastically delayed with one lane open, the OPP said.

Highway 404 southbound saw some problems, too, when a collision briefly closed three lanes and a shoulder near Finch Ave around 7 a.m., though all lanes have re-opened since.

In Mississauga, a collision occurred around 7:10 a.m. and blocked the middle lane on eastbound Highway 403 between Erin Mills Pkwy. and Mavis Rd., the OPP reported.

Schmidt also said that Highway 400 southbound is being closed for several hours starting from 7:20 a.m. on Thursday morning due to repairs on a highway sign that has been struck and damaged.

All lanes on Highway 400 southbound will be entirely closed between Aurora Rd. and King Rd.