He said it occurred in the eastbound collector lanes of Highway 401 east of Dixie Road at about 6 p.m.
Four people in all were taken to hospital, where the Toronto man was pronounced dead.
Schmidt said next of kin are being notified and police are not going to release the man’s name.
Police are still investigating the collision. The stretch of Highway 401 eastbound at Dixie Road and nearby access ramps that were closed have since been reopened.
Anyone with information or dash cam video is being urged to contact Port Credit OPP at (905) 278-6131.